Professor of School of Life Sciences,University of Science & Technology of China |
Tel: 86-551-63603046 Fax:86-551-63603046 e-mail: lwniu@ustc.edu.cn |
Personal Profile
a) Bachelor of Science, School of Life Sciences, University of Science and Technology of China, 1982
b) M.S. Institute of Biophysics of Chinese Academy of Sciences, 1986
· Working experience
1987-1989 Lecturer
1989-1995 Associate professor
1995-present Professor
1993 Visiting associate professor in Dept. of Biology, Purdue University
1993, 1995-1996 Visiting associate research professor, in Dept. of Biology, Purdue University
Research Interests
We are interested in transcription factors, especially the complexes related to transcription elongation. These factors interact with polymerase and/or mRNA and regulate elongation. We study the functions and structures of these proteins and complexes by biochemstry and crystallographic method.
We are interested in proteins and complexes invloved in vesicular transport process;
We are also interested in the functions and structures of snake venom proteins that interact with .
Selected Publications
1. Li H, Tong S, Li X, Shi H, Ying Z, Gao Y, Ge H, Niu L, Teng M. Structural basis of pre-mRNA recognition by the human cleavage factor Im complex. Cell Res. 2011 Jul;21(7):1039-51. doi: 10.1038/cr.2011.67.
2. Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, Niu L, Teng M. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12277-82.
3. Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog G, Teng M, and Niu L. (2008) Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation. Structure 16, 1649-1658.
4. Guo M, Teng M, Niu L, Liu Q, Huang Q, Hao Q. (2005) Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a K+ channel inhibitor-like fold. Journal of Biological Chemistry;280(13):12405-12412.
5. Wang D, Guo M, Liang Z, Fan J, Zhu Z, Zang J, Zhu Z, Li X, Teng M, Niu L, Dong Y, Liu P. (2005) Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. Journal of Biological Chemistry;280(24):22962-22967.
6. Liu Y, Hu Y, Li X, Niu L and Teng M.(2010)The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA Biochemistry-US. 49(13):2890-6.
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