Tengchuan Jin, Ph.D.

Professor, Ph.D. program of Biochemistry and Molecular Biology

Phone: +86-551-63600720                                                

E-mail: jint@ustc.edu.cn

Lab Website: Tjlab.ustc.edu.cn

Mailing Address: Biomedical Science Building, Rm 304 Mid-campus, USTC Hefei, Anhui 230027 China

Personal Profile

Dr. Jin graduated from the University of Science and Technology of China (USTC) in 2003 with a Bachelor’s Degree in Biology and received his Ph.D. degree in Molecular Biochemistry and Biophysics (MBB) from the Illinois Institute of Technology (IIT) in 2008. In 2008, he received the Sigma Xi Award from the Illinois Institute of Technology for Outstanding Accomplishments in Research and Scholarship.

During 2008-2014, Dr. Jin did his Postdoctoral training with Dr. Tsan Xiao at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). In the beginning of 2015, Dr. Jin joined the School of Life Sciences at the University of Science and Technology of China as a Tenure-Track Investigator and started the Laboratory of Structural Immunology.

Research Interests

The long-term research goal of the Laboratory of Structural Immunology is to use molecular, biochemical, and immunological methodologies to expand the understanding of infectious as well as autoimmune diseases, and to improve the quality of life for patients. We are particularly interested in the following four major research areas:

1. Structural biology of the innate immune receptors

2. Structure and function of inflammasome

3. Molecular mechanism of microbe-host interactions

4. Protein engineering and drug discovery

   Selected Publications (#First author, *Corresponding author):

5. Liu M, Zhou K, Xu Z, Ma H, Cao X, Yin X, Zeng W, Zahid A, Fu S, Ni K, Ye X, Zhou Y, Bai L, Zhou R, Jin T. Crystal Structure of Caspase-11 CARD Provides Insights into Caspase-11 Activation (2020). Cell Discovery.

6. Mekonnen D, Mengist HM, Derbie A, Nibret E, Munshea A, He H, Li B^*, Jin T^*. Diagnostic accuracy of serological tests and kinetics of SARS-COV-2 antibody: A systematic review and meta-Analysis. Reviews In Med Virology

7. Tao W, Wang X, Zhang G, Guo M, Ma H, Zhao D, Sun Y, He J, Liu L, Zhang K, Wang Y, Weng J, Ma X, Jin T^*, Zhu S^*(2020). Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection. Protein & Cell. doi: 10.1007/s13238-020-00778-8.

8. Ma H^#, Zhao D^#, Zeng W^#, Yang Y, Hu X, Zhou P, Weng J, Cheng L, Zheng X^*, Jin T^*(2020). Decline of SARS-CoV-2-specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge. Sci. China. Life Sci.  doi: 10.1007/s11427-020-1805-0

9. Guo C^#, Li B^#, Ma H, Wang X, Cai P, Yu Q, Zhu L, Jin L, Jiang C, Fang J, Liu Q, Zong D, Zhang W, Lu Y, Li K, Gao X, Fu B, Liu L, Ma X, Weng J, Wei H, Jin T^*, Lin J^*, Qu K^* (2020). Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm. Nat Commun.  11(1):3924.

10. Li WY, Li Y, Chen YL, Hu JJ, Mengist HM, Liu GM, Jin T^*, Cao MJ^* (2020). Characterization and crystal structure of prolyl endopeptidase from abalone (Haliotis discus hannai). Food Chem. 333:127452.

11. Li Y, Hu X, Tu Y, Wu T, Wang B, Ma H, Zeng W, Zhao D, Mengist HM, Kombe AJK, Zheng M, Xu Y^*, Jin T^* (2020). A low viral dose in COVID-19 patient: A case report. Frontiers in Public Health. 8:339. doi: 10.3389/fpubh.2020.00339

12. Fan X, Wang Y, Guo F, Zhang Y, Jin T^* (2020). Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs. Int J Biol Macromol. S0141-8130(20)33812-5.

13. Ma H^#, Zeng W^#, He H^#, Zhao D, Jiang D, Zhou P, Cheng L, Li Y^*, Ma X^*, Jin T^* (2020). Serum IgA, IgM, and IgG responses in COVID-19. Cell Mol Immunol. doi: 10.1038/s41423-020-0474-z.

14. Zeng W, Liu G, Ma H, Zhao D, Yang Y, Liu M, Mohammed A, Zhao C, Yang Y, Xie J, Ding C, Ma X, Weng J, Gao Y, He H^*, Jin T^* (2020). Biochemical characterization of SARS-CoV-2 nucleocapsid protein.  Biochem Biophys Res Commun. 527(3):618-623. doi: 10.1016/j.bbrc.2020.04.136.

15. Mengist HM, Fan X, Jin T^* (2020). Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease M^pro. Signal Transduct Target Ther. 5(1):67. doi: 10.1038/s41392-020-0178-y.

     

    For complete list of publications, please see Dr. Tengchuan Jin’s PubMed link and Google Scholar page.

     

    We welcome students with backgrounds in Physics, Chemistry, Computer Science, Biology or Medicine join our group. We do not discriminate race, sex, age, and believe.