EDUCATION AND RESEARCH EXPERIENCE Xuebiao Yao, PhD, is a Cheung Kong Professor (1998) and recipient of NSFC Outstanding Young Scientist Award (1999). He graduated, with a PhD in Molecular & Cell Biology, from the University of California-Berkeley in 1995 followed by a postdoctoral fellowship at the University of California-San Diego. He accepted a tenure-track assistant professorship at the University of Wisconsin-Madison in 1997. He joined the University of Science & Technology of China in 1999 to build the Laboratory for Cellular Dynamics to delineate the organelle dynamics and plasticity control underlying cell fate decision in mitosis using a palette of optical sensors and chemical modulators. The training philosophy in the Laboratory for Cellular Dynamics is to transform motivated talents into future star scientists in biomedical sciences. Many trainees from the Laboratory for Cellular Dynamics were recognized with Qing Qian Scholarship, Ray Wu Prize, CAS Outstanding Dissertation Award, keynote speaker of Harvard graduation, and Damon Runyon Research Fellowship etc. Dr. Yao serves on many editorial boards (Cell Res., Cell Discovery, JBC, JMCB etc.) and heads the MOE Key Laboratory for Cellular Dynamics, Anhui Key Laboratory for Cellular Dynamics & Chemical Biology. The active research areas in Dr. Yao’s group include: centromere plasticity & stemness control; chemical biology of mitosis & metastasis; organoids architect & plasticity control; single molecule & super-resolution imaging. The current research supports were generously provided by Chinese Academy of Sciences, Natural Science Foundation of China, and Ministry of Science & Technology of China.
RESEARCH INTERESTS Cellular mechanisms involved in establishment and maintenance of cell polarity using gastric epithelial cells as a model system. How Helicobacter pylori cytotoxins such as VacA perturb genomic stability of gastric parietal cells using a novel 3D culture system. Mitotic chromosome segregation and genomic stability: Protein-protein interactions at the kinetochore is orchestrated during cell division and what happens when specific protein-protein interaction is perturbed in real-time live cells using optical reporters. SELECTED PUBLICATIONS 1. Song X#, Yang F#, Yang T#, Wang Y#, Ding M#, Li L#, Xu P, Liu S, Dai M, Chi C, Xiang S, Xu C, Li D, Wang Z, Li L, Hill DL, Fu C, Yuan K, Li P, Zang J, Hou Z, Jiang K, Shi Y, Liu X*, Yao X*. Phase separation of EB1 guides microtubule plus-end dynamics. Nat Cell Biol.25(1):79-91. (2023)(Highlighted by Nature Cell Biology) 2. Tian T#, Chen L#, Dou Z#, Yang Z#, Gao X*, Yuan X, Wang C, Liu R, Shen Z, Gui P, Teng M, Meng X, Hill DL, Li L, Zhang X, Liu X, Sun L*, Zang J*, Yao X*. Structural insights into human CCAN complex assembled onto DNA. Cell Discov. 8(1):90. (2022) 3. Song X#, Yang F#, Liu X#, Xia P#, Yin W, Wang Z, Wang Y, Yuan X, Dou Z, Jiang K, Ma M, Hu B, Zhang R, Xu C, Zhang Z, Ruan K, Tian R, Li L, Liu T, Hill DL, Zang J*, Liu X*, Li J*, Cheng J*, Yao X*. Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. Nat Chem Biol. 17(12):1314-1323. (2021) (Highlighted by Nature Chemical Biology) 4. Xu L#, Ali M#, Duan W#, Yuan X*, Garba F, Mullen M, Sun B, Poser I, Duan H, Lu J, Tian R, Ge Y, Chu L, Pan W, Wang D, Hyman A, Green H, Li L, Dou Z*, Liu D*, Liu X*, Yao X*. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. Cell Rep. 36(2):109343. (2021) 5. Liu X, Liu X, Wang H, Dou Z, Ruan K, Hill DL, Li L, Shi Y,Yao X*. Phase separation drives decision making in cell division.J Biol Chem. 295(39):13419-13431. (2020) Review. (Recommended by F1000) 6. Huang Y#, Lin L#, Liu X#, Ye S#, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R*, Yao X*. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 29(7):562-578. (2019) (Highlighted by Cell Research) 7. Yu H, Yang F, Dong P, Liao S, Liu WR, Zhao G, Qin B, Dou Z, Liu Z, Liu W, Zang J, Lippincott-Schwartz J, Liu X, Yao X*. NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation. Cell Res. 29(8):666-679. (2019) 8. Yao X*, Smolka AJ. Gastric parietal cell physiology and Helicobacter pylori-induced disease. Gastroenterology. 156(8):2158-2173. (2019) 9. Mo F#, Zhuang X#, Liu X*, Yao PY, Qin B, Su Z, Zang J, Wang Z, Zhang J, Dou Z, Tian C, Teng M, Niu L, Hill DL, Fang G, Ding X, Fu C, Yao X*. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nat Chem Biol. 12(4):226-32. (2016) (Highlighted by Nature Chemical Biology) 10. Dou Z#, Liu X#, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A. 112(33):E4546-55. (2015) 11. Zhao X#, Wang D#, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Liu D, Yu X, Chen Y, Chen Z, Teng M, Ding X, Yao X*. Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. Proc Natl Acad Sci U S A. 110(27):11023-8. (2013) 12. Yao X*, Li D, Pei G*. In focus: molecular and cell biology research in China. Nat Rev Mol Cell Biol. 14(9):600-6. (2013) 13. Xia P#, Wang Z#, Liu X, Wu B, Wang J, Ward T, Zhang L, Ding X, Gibbons G, Shi Y, Yao X*. EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 109(41):16564-9. (2012)(Recommended by F1000) 14. Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X*, Teng M*. The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nat Commun. 3:782. (2012) 15. Chen J#, Yao Y#, Gong C#, Yu F#, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao X*, Song E*. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 19(4):541-55. (2011) (Recommended by F1000) 16. Ding X#, Yan F#, Yao P, Yang Z, Wan W, Wang X, Liu J, Gao X, Abrieu A, Zhu T, Zhang J, Dou Z, Yao X*. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 20(12):1386-9. (2010) 17. Jiang K, Wang J, Liu J, Ward T, Wordeman L, Davidson A, Wang F, Yao X*. TIP150 interacts with and targets MCAK at the microtubule plus ends. EMBO Rep. 10(8):857-65. (2009) 18. Fang Z#, Miao Y#, Ding X, Deng H, Liu S, Wang F, Zhou R, Watson C, Fu C, Hu Q, Lillard JW Jr, Powell M, Chen Y*, Forte JG, Yao X*. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. Mol Cell Proteomics. 5(8):1437-49. (2006) |
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